Biologic Problems in Orthodontia

Biologic agents in psoriasis.

This paper reviews the new biologic agents that selectively block the immunologic steps implicated in the pathogenesis of psoriasis. Four strategies have been targeted: reduction of the number of pathogenic T cells; inhibition of T-cell activation and migration; modulation of the immune system; and blockage of the activity of inflammatory cytokines. There are three classes: monoclonal antibodie...

The Evolving Use of Computer-aided Drafting, Design, and Manufacturing in Orthodontia

Computer-aided drafting and design (CADD) is a computer-based program that improves the efficiency of product design and components both inside and outside of engineering. In recent years the use of CADD in dentistry, more commonly known as computer-aided dentistry, has become commonplace, allowing doctors and patients to individually design treatment with the result visible through computer-ge...

The Biologics Price Competition and Innovation Act: Potential Problems in the Biologic-Drug Regulatory Scheme

2 Biologic

In this paper we explore the boundary between biology and the study of formal systems (logic).

Biologic agents in systemic vasculitis.

The treatment of systemic necrotizing vasculitis has made great strides in both efficacy and outcomes. Standard therapies, however, are associated with numerous side effects, and not all patients will respond to conventional immunosuppression. These realities have prompted the search for safer and more efficacious treatments, most notably among biologic agents. For example, the role of TNF-α in...